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Yongyong Li, Ph.D. Chao Lin, Ph.D.
Donglu Shi, Ph.D Peng Zhao, Ph.D. Peng Zhao, Ph.D.
Yilong Wang, Ph.D.
Bingbo Zhang, Ph.D. Donglu Shi, Ph.D
Yilong Wang, Ph.D.
 

 


李永勇

研究员,同济大学医学院PI(首席科学家)
同济大学医学院生物医学工程与纳米科学研究院
地址:上海杨浦区赤峰路67号
邮编:200092
电话/传真:86-021-65983706-815
Email: yongyong_li(at)tongji(dot)edu(dot)cn

 
 

 

工作简历:
2009年 讲师 同济大学
2011年 副研究员 同济大学(破格)
2015年 研究员 同济大学(破格)

荣誉与获奖:
2016年 入选同济大学“青年”百人计划
2012年 入选上海市“启明星”青年科技人才计划
2011 年 入选同济大学骨干类“英才计划”
2011年 上海市教委“晨光计划”
2011年 同济大学纳米院优秀研究生导师奖
2010 年 同济大学纳米院优秀科研奖
2010 年 湖北省优秀博士论文奖

研究经历:
2009年毕业于武汉大学高分子化学与物理专业,博士期间主要从事生物医用高分子研究。独立开展工作后,致力于利用分子自组装方法构建高效递送化疗药物/基因的纳米药物载体,以期为临床中重大疾病尤其是癌症治疗提供潜在方及手段。针对传统敏感纳米载体在刺激下,结构变化小导致药物控释能力不足的问题,提出与发展崩解型纳米载体新设计,并围绕该设计载体结构调控开展系列工作,并探索其在基因、蛋白、化药不同功能分子递送领域的应用。基于先期工作基础,当前致力于生物材料与免疫交叉领域研究。发展了纳米蛋白疫苗的孔板合成新方法,该方法具有高通量、绿色、温和、可控等一系列特点,为纳米疫苗构建提供了新型平台技术,当前正不断挖掘与拓展新技术在免疫领域的应用潜力。

迄今正式发表SCI论文50余篇,发表第一作者论文15篇,包括Advanced materials (IF:14.8)、Small (IF:8.3)、 ACS Nano (IF: 12) 等著名国际SCI源刊;通讯作者论文40余篇,发表杂志包括著名杂志Small (IF:7.8),Chemical Communications (IF:6.4)。论文他引总计超过1000次, H index 23。发表研究工作受到国际同行关注,近期被国际知名杂志邀请综述本领域研究进展。两篇国际著名纳米医学杂志综述也分别报道了本课题研究工作。另中国科学也撰文对本课题组2012年的研究工作进行专题报道。一篇论文成为ESI高频引用论文及被中国科学专题报道(Small 2012)。近期连续在知名期刊包括Nanomedicine(IF:5.413),Journal of Biomedical Nanotechnology(IF:5.338)上发表review。被邀请与国际学者合作编著“Methods in Molecular biology, with the topic of "siRNA delivery methods",及与国内外学者合作编著“Nanomaterials for Tumor Targeting Theranostics”。

研究方向:
目前主要研究方向为:
1基因/药物载体系统:发展高效蛋白载体平台用于基因与药物智能递送
2纳米免疫研究:模仿病毒特性,发展新型免疫技术
3生物材料与细胞界面:探索细胞表面化学或修饰对细胞命运的调控

项目
在研主持项目:
1同济大学青年百人计划;蛋白纳米载体系统;起止时间:2017/01~2019/12;总经费:200万;
2国家自然科学面上项目;批准号:51473124/E031002;阳离子高分子序列结构与基因递送效率;起止时间:2015/01~2018/12;总经费:78万;
3国家自然科学面上项目;批准号:51773154/E031002;项目名称: 抗原蛋白可控组装:“自运载”纳米疫苗探索;起止时间:2018/01~2022/12;总经费:61万;

结题项目:
上海市青年科技启明星计划(20 万);国家自然科学面上项目(No.51173136, 60万);国家自然科学青年基金(No.21004045,19万);中央高校基本科研业务费专项资金(80 万);上海市教委人才培养项目;上海市自然科学基金(No.10ZR1432100,10万);国家重大科学研究计划(No.2013CB967500,负责经费:80 万)


代表论文:

1 Huiyun Wen, Haiqing Dong, Jie Liu, Aijun Shen, Yongyong Li*, Donglu Shi, Redox-mediated dissociation of PEG–polypeptide based micelles for on-demand release of anticancer drugs, 2016, J. Mater. Chem B, 4, 7859-7869. (IF=4.543)
2 Junping Ma, Haiqing Dong, Haiyan Zhu, Cheuk-Wing Li, Yongyong Li*and Donglu Shi, Deposition of gadolinium onto the shell structure of micelles for integrated magnetic resonance imaging and robust drug delivery systems, J. Mater. Chem. B, 2016, 4, 6094. (IF=4.543)
3 Dou Du, Kun Wang, Ya Wen, Yan Li, Yongyong Li*, Photodynamic Graphene Quantum Dot: Reduction Condition Regulated Photo-activity and Size Dependent Efficacy, ACS Appl Mater Interfaces. 2016, 3287-3294. (IF=7.504)
4 Ya Wen,Haiqing Dong, Yan Li,a Aijun Shen, and Yongyong Li*, Nano-assembly of bovine serum albumin driven by rare-earth-ion (Gd) biomineralization for highly efficient photodynamic therapy and tumor imaging, J. Mater. Chem. B, 2016, 4, 743-751. (IF=4.543)
5 Xiaojun Cai, Yongyong Li*, Reversible PEGylation and Schiff-base linked imidazole modification of polylysine for high-performance gene delivery. J Mat Chem B. 2015;3:1507-17. (IF=4.543)
6 Haiqing Dong H, Min Tang, Yongyong Li*, Donglu Shi. Disulfide-bridged cleavable PEGylation in polymeric nanomedicine for controlled therapeutic delivery. Nanomedicine. 2015;10:1941-58. (IF=4.727)
7 Yan Li, Haiqing Dong, Donglu Shi*, Yongyong Li*. Graphene-based Nano-vehicles for Photodynamic Medical Therapy. International Journal of Nanomedicine, 2015, 10, 2451. (IF:4.3)
8 Xiaojun Cai, Haiyan Zhu, Haiqing Dong, Jiansheng Su, Yongyong Li∗, and Donglu Shi∗,Suppression of VEGF by Reversible-PEGylated Histidylated Polylysine in Cancer Therapy, Advanced Healthcare Materials, 2014, 3, 1818–1827. (IF=5.11)
9 Haiqing Dong†, Chunyan Dong†, Tianbin Ren, Yongyong Li∗, and Donglu Shi∗,Surface-Engineered Graphene-Based Nanomaterials for Drug Delivery, J. Biomed. Nanotechnol. 2014, 10, 10, 2086–2106. (IF=4.521)
10. Zhu Haiyan,, Dong Chunyan, Dong Haiqing, Ren Tianbin, Wen Xuejun, Su Jiansheng, Li Yongyong*, Cleavable PEGylation and Hydrophobic Histidylation of Polylysine for siRNA Delivery and Tumor Gene Therapy. ACS Appl Mater Interfaces. 2014, 6: 10393 - 407. (IF=7.504)
11 Yongyong Li, Junping Ma, Haiyan Zhu, Xiaolong Gao, Haiqing Dong, and Donglu Shi, Green Synthetic, Multifunctional Hybrid Micelles with Shell Embedded Magnetic Nanoparticles for Theranostic Applications, ACS Appl. Mater. Interfaces 2013, 5, 7227-7235. (IF=7.504)
12 Yongyong Li, Lan Li, Haiqing Dong , Xiaojun Cai, Tianbin Ren, Pluronic F127 nanomicelles engineered with nuclear localized functionality for targeted drug delivery, Mater Sci Eng C 2013, 33, 2698-2707. (IF=4.164)
13 Meng Chu, Chunyan Dong, Haiyan Zhu, Xiaojun Cai, Haiqing Dong, Tianbin Ren, Jiansheng Su and   and  Yongyong Li*, Biocompatible polyethylenimine-graft-dextran catiomer for highly efficient gene delivery assisted by a nuclear targeting ligand, Polym. Chem., 2013, 3, 2561-2569. (IF=5.375)
14 Xiaojun Cai, Haiqing Dong, Junping Ma, Haiyan Zhu, Wei Wu, Meng Chu, Yongyong Li* and Donglu Shi* Effects of spatial distribution of the nuclear localization sequence on gene transfection in catiomer–gene polyplexes, J. Mater. Chem. B, 2013, 1, 1712-1721. (IF=4.543)
15 Tianbin Ren, Lan Li, Xiaojun Cai, Haiqing Dong, Shumeng Liu and Yongyong Li*, Engineered polyethylenimine/graphene oxide nanocomposite for nuclear localized gene delivery, Polym. Chem., 2012, 3, 2561-2569. (IF=5.375)
16 Haiqing Dong, Yongyong Li*, Jin Yu, Yanyan Song, Xiaojun Cai, Jiaqiang Liu, Jiaming Zhang, RC Ewing, Donglu Shi*, A Versatile Multi-Component Assembly via β-cyclodextrin Host-Guest Chemistry on Graphene for Biomedical Applications, Small, 2013, 9,446-456. (IF=8.643)
17 Yanna Cui, Haiqing Dong, Xiaojun Cai, Deping Wang, and Yongyong Li*, Mesoporous Silica Nanoparticles Capped with Disulfide-Linked PEG Gatekeepers for Glutathione-Mediated Controlled Release, ACS Appl. Mater. Interfaces, 2012, 4, 3177-3183. (IF=7.504)
18 Xiaojun Cai, Chunyan Dong, Haiqing Dong, Gangmin Wang, Giovanni M. Pauletti, Xiaojing Pan, Huiyun Wen, Isaac Mehl, Yongyong Li* and Donglu Shi, Effective Gene Delivery Using Stimulus-responsive Catiomer Designed with Redox-sensitive Disulfide and Acid-labile Imine Linkers, Biomacromolecules, 2012, 13, 1024-1034. (IF=5.246)
19 Hui-Yun Wen, Chunyan Dong, Haiqing Dong, Aijun Shen, Wenjuan Xia, Xiaojun Cai, Yanyan Song, Xuequan Li, Yongyong Li* and Donglu Shi,Engineered Redox-Responsive PEG Detachable Mechanism in PEGylated Nano-graphene Oxide for Intracellular Drug Delivery, Small, 2012, 8, 760-769. (IF=8.643)
20 Xiao-Jun Cai, Hai-Qing Dong, Wen-Juan Xia, Hui-Yun Wen, Xue-Quan Li, Jin-Hai Yua, Yongyong Li* and Dong-Lu Shi, Glutathione-mediated Shedding of PEG Layers Based on Disulfide-Linked Catiomers for DNA Delivery, Journal of Materials Chemistry, 2011, 21, 14639-14645(IF=4.543)
21 Xue-Quan Li, Hui-Yun Wen, Hai-Qing Dong, Wei-Ming Xuea, Giovanni M. Paulettic, Xiao-Jun Cai, Wen-Juan Xia, Donglu Shi and Yongyong Li*, Self-assembling Nanomicelles of a Novel Camptothecin Prodrug Engineered with a Redox-responsive Release Mechanism, Chem. Commun., 2011, 47, 8647-8649. (IF=6.319)
22  Hui-Yun Wen, Hai-Qing Dong, Wen-juan Xie, Yongyong Li*, Kang Wang, Giovanni M. Pauletti and Dong-Lu Shi, Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery Chem. Commun., 2011, 47, 3550-3552.(IF=6.319)
23  Hai-Qing Dong, Yong-Yong Li*, Hui-Yun Wen, Meng Xu, Li-Jian Liu, Zhuo-Quan Li, Fang-Fang Guo, Dong-Lu Shi *, Highly Efficient Drug Delivery Nanosystem by L-Phenylalanine Triggering Based on Supramolecular Polymer Micelles. Macromolecular Rapid Communications, 2011, 32, 540-545. (IF=4.265)
24  Yong-Yong Li, Shou-Hu Hua, Wang Xiao, Hui-Yuan Wang, Xiao-Hua Luo, Cao Li, Si-Xue Cheng, Xian-Zheng Zhang, and Ren-Xi Zhuo, Dual-Vectors of Anti-Cancer Drugs and Genes Based on pH-Sensitive Micelles Self-Assembled from Hybrid Polypeptide Copolymers. Journal of Materials Chemistry, 2011, 21,3100-3106. (IF=4.543)
25 Yong-Yong Li, Han Cheng, Jing-Ling Zhu et al. Temperature and pH sensitive multi-colored micellar complexes. Advanced Materials, 2009, 21, 2402-2406. (IF=19.791)
26 Yong-Yong Li, Han Cheng, Zhi-Guo Zhang et al. Cellular internalization and in vivo tracking of thermosensitive luminescent micelles based on luminescent lanthanide chelate. ACS Nano, 2008, 2, 125-133. (IF=13.942)
27 Hai-Qing Dong,* Yong-Yong Li* (共同第一作者), Shao-Jun Cai et al. A facile one-pot construction of supramolecular polymer micelles from a-cyclodextrin and poly(e-caprolactone). Angewandte Chemie International Edition, 2008, 47, 5573-5576. (IF= 11.994)
28 Yong-Yong Li, Xian-Zheng Zhang, Gwang-Chol Kim et al. Thermosensitive Y-shaped micelles of poly(oleic acid-Y-N-isopropylacrylamide) for drug delivery,  Small, 2006, 2, 917–923. (IF= 8.643)
29 Yong-Yong Li, Xian-Zheng Zhang, Han Cheng, et al. Novel stimuli-/pH- responsive micelle self-assembled from Y-shaped P(UA-Y-NIPAAm) copolymer for drug delivery. Biomacromolecules, 2006, 7, 2956-2960. (IF= 5.246)
30 Yong-Yong Li, Xian-Zheng Zhang, Han Cheng, et al. Self-assembled, thermosensitive PCL-g-P(NIPAAm-co-HEMA) micelles for drug delivery. Macromolecular Rapid Communications, 2006, 27, 1913-1919. (IF= 4.265)

 

邀请编著:
1 Nanomaterials for Tumor Targeting Theranostics, 负责章节:Polymeric Nanosystems for Targeted Theranostics,出版社:World Scientific Publishing.
2 Methods in Molecular biology, with the topic of "siRNA delivery methods, 负责章节:Disulfide Bridged PEG-cleavable Dendrigraft of poly-L-lysine for Gene Therapy, 出版社:Springer.

专利情况

  1. 李永勇,王坤,任天斌,温姝曼,董海青  一种蛋白自组装新型纳米疫苗及其制备方法 申请号:201710307288.0.
  2. 李永勇, 董海青, 徐梦, 时东陆, 对氨基酸敏感的超分子聚合物胶束药物载体的制备方法,申请号:201010281371.3公开号:CN102399369A授权号:102399369B  
  3. 李永勇,沈爱军, 赵志磊, 王培军, 董海青, 一种用于MRI造影剂的新型石墨烯纳米载体,公开号: CN102397563A,授权号102397563B  
  4. 李永勇, 温慧云, 董海青, 王康, 沈爱军, 徐梦, 一种壳层可脱落的聚合物胶束药物载体,公开号:CN102397236A。
  5. 董海青, 李永勇,徐梦,赵志磊,时东陆, 一种超分子聚合物胶束的制备方法, 申请号:201010176116.2,公开号:ZL 201210245010,授权号:102241825B  
  6. 董海青, 李永勇, 徐梦, 沈爱军, 温慧云, 时东陆, 用于光动力治疗的纳米氧化石墨烯载体的制备方法,公开号: CN102370980A

 



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