Gold Nanoparticles as Drug Delivery Vectors for Photodynamic Therapy of Cancers
 
报告人:成昱博士
时 间:6月8日(周五)上午10:00
地 点:同济大学南校区实训楼纳米院219会议室
摘要:

Gold nanoparticle-drug conjugates have attracted increasing attention in targeted drug delivery for photodynamic cancer therapy. Due to the favorable surface area, hundreds of molecules can be attached to a 5 nm gold nanoparticle. The versatile delivery of the nanoparticle surface plays a vital role in drug delivery. Both covalent and non-covalent drug binding can be achieved by designing the functionality of the nanoparticle surface. Due to the design of the gold nanoparticle carrier, using amphiphilic polymers, the drug delivery can be facilitated based on its size and the enhanced permeability and retention in the tumor tissue. In addition, targeted delivery of photodynamic therapy (PDT) drugs can be achieved by modification of the carrier surface with active targeting ligands. Compared to the covalent approach, the non-covalent delivery approach of the hydrophobic PDT drug Pc 4 through gold nanoparticles has shown better release from the particles and photocytotoxicity in cancer cells. In vivo studies in cancer bearing mice have shown an efficient delivery of the drug into the target tumors by the nanoparticle vectors. After modification with the conjugates with an EGF peptide, the drug uptake into the tumor cells has been dramatically improved due to the combination of active and passive targeting compared to untargeted conjugates. In vivo fluorescence and histochemical analysis show that the gold nanoparticles and the drug can be removed from the body through renal clearance and the hepatobiliary system within days after drug administration.

个人简介:

成昱获武汉大学学士学位及有机化学硕士学位;2006年赴美深造,2011年获美国凯斯西储大学物理化学博士学位,随后在美国芝加哥大学医学院脑癌研究中心从事博士后研究至今。其研究包括生物医用纳米材料,药物传输及药物释放,磁性纳米药物,以及纳米材料与干细胞的联用。主要学术成果发表在Journal of the American Chemical Society, Small 及Langmuir等国际知名高水平刊物上。创新成果被国际同行广泛认可,文章他引次数已经多达150次,同时包括雅虎等在内的国内外知名媒体对其研究突破进行了详细报道。 相关研究成果还被 Langmuir杂志选为2010年26卷第4期的期刊封面。 由于在以纳米药物载体在光动力治疗研究中取得的突出成果,获邀贡献了由世界著名出版公司Elsevier 出版的“Comprehensive Nanoscience and Technology”丛书中的“Nanoparticles for Photodynamic Therapy” 该章节。

 
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