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The 10th SEMINAR of iNANO
 
Host: Dr. 林超
 
1. Safety Education
Time: 2:00-2:15PM, Dec. 18th (Tue.)
 
2. Progress Report
Title: Lateral Flow Immunochromatographic Assay for Sensitive Pesticide Detection by Using Fe3O4 Nanoparticle Aggregates as Color Reagents
Speaker: 阎俊(上海海洋大学硕士)
Time: 2:15-2:45PM, Dec. 18th(Tue.)
Abstract: Magnetic Fe3O4 particle aggregates were prepared by cross-linking Fe3O4 nanoparticles bearing surface carbonyl groups with poly- L-lysine. Upon further coupling with antiparaoxon methyl polyclonal antibody, there sultant particle aggregate-based probes were used in a lateral flow immunochromatographic assay (LFIA) of pesticide residue of paraoxon methyl. The results were compared with that achiev ed by using the mother Fe3O4 nanoparticles. More quantitative results on the signal amplification effect endowed by the controlled aggregation of Fe3O4 nanoparticles were extracted by relative optical density analysis. Under optimized conditions, a detection limit of 1.7ng/mL for paraoxon methyl was achieved by using the particle aggregates, which is almost 40-fold lower than that based on the mother Fe3O4 nanoparticles.
 
3. literature Reading
Speaker: 李恬
Title: Mesoporous Multifunctional Upconversion Luminescent and Magnetic “Nanorattle” Materials for Targeted Chemotherapy
Time: 3:00-3:30PM, Dec. 18th(Tue.)
Abstract: Nanorattles consisting of hydrophilic, rare-earthdoped NaYF4 shells each containing a loose magnetic nanoparticle were fabricated through an ion-exchange process. The inner magnetic Fe3O4 nanoparticles are coated with a SiO2 layer to avoid iron leaching in acidic biological environments. This multifunctional mesoporous nanostructure with both upconversion luminescent and magnetic properties has excellent water dispersibility and a high drug-loading capacity. The material emits visible luminescence upon NIR excitation and can be directed by an external magnetic field to a specific target, making it an attractive system for a variety of biological applications. Measurements on cells incubated with the nanorattles show them to have low cytotoxicity and excellent cell imaging properties. In vivo experiments yield highly encouraging tumor shrinkage with the antitumor drug doxorubicin (DOX) and significantly enhanced tumor targeting in the presence of an applied magnetic field.
 
Location: Meeting Room 219
 
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The Institute for Advanced Materials and Nano Biomedicine (iNANO),
Tongji University, 67 Chifeng Road, Shanghai, 200092, China
Tel: +86-021-65988029    Email: inano@tongji.edu.cn
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