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Chao Lin, Ph.D.
Peng Zhao, Ph.D. Jinhu Yang, Ph.D.
Fangfang Guo, Ph.D.
Yilong Wang, Ph.D.
Yongyong Li, Ph.D.
 

 

Bingbo Zhang, Ph.D.

Associate Research Scientist
The Institute for Advanced Materials & Nano Biomedicine
Tongji University
Address:67 Chifeng Rd. Shanghai, 200092, P.R. China
Tel/Fax:+086-021-65983706-819
Email: bingbozhang@tongji.edu.cn

 
 

EDUCATION

09/2006- 03/2009 Ph. D,Polymeric materials,Tianjin University

09/2004-07/2006 M.S.,Polymeric materials,Tianjin University

09/2000-07/2004 B.S.,Polymeric materials,Soochow University
 


RESEARCH INTEREST

 1. Molecular Diagnostics based on Nanomaterials and Nanotechnology
The integration of nanotechnology with biology and medicine is expected to produce major advances in molecular diagnostics. We specialise in design and synthesis of functional nanomaterials, including multi-color quantum dots, rare-earth up-conversion nanoparticles, fluorescent gold nanoclusters, magnetic nanoparticles and metallic nanoparticles. Such nanomaterials can be used as specific bioprobes in the field of molecular diagnostics after labeled with specific ligands (antibody, peptide, DNA, oligonucleotides, aptamer, etc).

2. In vivo Molecular Imaging based on Novel Contrast Agents
The in vivo imaging can be enhanced through the injected contrast agents (CAs). We focus on the design and preparation of novel CAs, including fluorescent probes, MRI CAs, CT CAs, and their multimodal CAs, according to the principles of biocompatibility, fine pharmacokinetics, targeting and clinical feasibility.

Biographical Sketch

Dr. Bingbo Zhang received his Ph. D in polymeric materials from the School of Material Science and Engineering, Tianjin University in 2009. His Ph. D dissertation mainly focused on the nanomaterials and nanotechnology in the filed of biomedical detection. He joined faculty at The Institute for Biomedical Engineering & Nano Science, Tongji University, Shanghai, in 2009. Dr. Zhang has published over 30 refereed papers in international journals with an H-index 13 (June, 2015). His research program is focused on biomedical nanotechnology, biomolecular engineering, molecular imaging, and In vitro molecular diagnostic (IVD). He is a recipient of the “Tongji university talent plan” Award, a member of the Chinese Chemical Society (CCS) and Chinese Society of Micro-Nano Technology (CSMNT). He is also an elected committee member of the Chinese Society of Biomedical Engineering (CSBE) - Branch of Nano medicine and engineering.

SELECTED PUBLICATIONS

40. Wang, Jiefei; Zhong, Yong; Wang, Xiao; Yang, Weitao; Bai, Feng*; Zhang, Bingbo*; Leanne Alarid, Bian, Kaifu; and Fan, Hongyou*; pH-Dependent Assembly of Porphyrin–Silica Nanocomposites and Their Application in Targeted Photodynamic Therapy, Nano Letters, 2017, 17 (11), 6916–6921. IF: 12.7
39. Zhang, Bingbo*; Yang, Weitao; Yu, Jiani; Guo, Weisheng; Wang, Jun; Liu, Shiyuan; Xiao, Yi*; Shi, Donglu*; Green Synthesis of Sub-10 nm Gadolinium-Based Nanoparticles for Sparkling Kidneys, Tumor, and Angiogenesis of Tumor-Bearing Mice in Magnetic Resonance Imaging, Advanced Healthcare Materials, 2017, 6(4):1600865. IF: 5.11
38. Yan, Kai; Yu, Jiani; Zhang, Bingbo*; Wu, Limin*; Novel Fluorinated Polymer-Mediated Upconversion Nanoclusters for pH/Redox Triggered Anticancer Drug Release and Intracellular Imaging, Macromolecular Chemistry and Physics, 2017, 218 (11): 1700090. IF: 2.5
37. Liu, Fengjun; Ye, Wen; Wang, Jun; Song, Fengxiang; Cheng, Yingsheng*; Zhang, Bingbo*; Parallel comparative studies on toxicity of quantum dots synthesized and surface engineered with different methods in vitro and in vivo, International Journal of Nanomedicine, 2017, 12: 5135-5148. IF: 4.3
36. Yang, Weitao; Guo, Weisheng; Chang, Jin*; Zhang, Bingbo*; Protein/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications, Journal of Materials Chemistry B, 2017, 5(3): 401-417. IF: 4.543
35. Zhang, Bingbo; Wang, Jun; Yu, Jiani; Fang, Xiangming*; Wang, Xiuli; Shi, Donglu*; Site-Specific Biomimetic Precision Chemistry of Bimodal Contrast Agent with Modular Peptides for Tumor-Targeted Imaging, Bioconjugate Chemistry, 2017, 28(2): 330-335, IF: 4.818
34. Yang, Weitao; Guo, Weisheng; Le, Wenjun; Lv, Guoxian; Zhang, Fuhe; Shi, Lei; Wang, Xiuli; Wang, Jun; Wang, Sheng; Chang, Jin*; Zhang, Bingbo*; Albumin-Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging-Guided Tumor-Targeted Photothermal Therapy, Acs Nano, 2016, 10(11): 10245-10257, IF: 13.942
33. Zhang, Jing; Hao, Guangyu; Yao, Chenfei; Yu, Jiani; Wang, Jun; Yang, Weitao; Hu, Chunhong*; Zhang, Bingbo*; Albumin-Mediated Biomineralization of Paramagnetic NIR Ag2S QDs for Tiny Tumor Bimodal Targeted Imaging in Vivo,  ACS Applied Materials & Interfaces, 2016, 8(26): 16612-16621, IF: 7.504
32. Zhang, Bingbo; Yu, Jiani; Liu, Chang; Wang, Jun; Han, Huanxing*; Zhang, Pengfei*; Shi, Donglu; Improving detection sensitivity by oriented bioconjugation of antibodies to quantum dots with a flexible spacer arm for immunoassay, RSC Advances, 2016, 6(55): 50119-50127, IF: 3.108
31. Du, Hongli; Yu, Jiani; Guo, Dongcai*; Yang, Weitao; Wang, Jun; Zhang, Bingbo*; Improving the MR Imaging Sensitivity of Upconversion Nanoparticles by an Internal and External Incorporation of the Gd3+ Strategy for in Vivo Tumor-Targeted Imaging, Langmuir, 2016, 32(4): 1155-1165, IF: 3.833
30. Wang, Sheng; Yang, Weitao; Du, Hongli; Guo, Fangfang; Wang, Hanjie; Chang, Jin*; Gong, Xiaoqun*; Zhang, Bingbo*; Multifunctional reduction-responsive SPIO&DOX-loaded PEGylated polymeric lipid vesicles for magnetic resonance imaging-guided drug delivery, Nanotechnology, 2016, 27(16): 165101, IF: 3.44
29. Zhang, Jing; Hao, Guangyu; Yao, Chenfei; Hu, Su; Hu, Chunhong*; Zhang, Bingbo*; Paramagnetic albumin decorated CuInS2/ZnS QDs for CD133(+) glioma bimodal MR/fluorescence targeted imaging, Journal of Materials Chemistry B, 2016, 4(23): 4110-4118, IF: 4.543
28. Xing, Xiaohong; Zhang, Bingbo*; Wang, Xiaohui; Liu, Fengjun; Shi, Donglu; Cheng, Yingsheng*; An "imaging-biopsy" strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots, Biomaterials, 2015, 48: 16-25, IF: 8.402
27. Yang, Weitao; Guo, Weisheng; Gong, Xiaoqun; Zhang, Bingbo*; Wang, Sheng; Chen, Na; Yang, Wentao; Tu, Yu; Fang, Xiangming; Chang, Jin*; Facile Synthesis of Gd-Cu-In-S/ZnS Bimodal Quantum Dots with Optimized Properties for Tumor Targeted Fluorescence/MR In Vivo Imaging, Acs Applied Materials & Interfaces, 2015, 7(33): 18759-18768, IF: 7.504
26. Guo, Weisheng; Yang, Weitao; Wang, Yu; Sun, Xiaolian; Liu, Zhongyun; Zhang, Bingbo*; Chang, Jin*; Chen, Xiaoyuan*, Color-tunable Gd-Zn-Cu-In-S/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging, Nano Research, 2014, 7(11): 1581-1591, IF: 7.354
25. Yang, Qiuhua; Wang, Xin; Yang, Jiumin; Li, Xue; Song, Tao; Gong, XiaoqQun; Zhang, Bingbo*; Chang, Jin*, Development of Quantum Dot-Based Lateral Flow Immunoassay System for Rapid Quantitative Detection of Human Chorionic Gonadotropin, Progress in Biochemistry and Biophysics, 2014,41(5): 497-507, IF: 0.341
24. Dai, Lingling; Liu, Yongkang; Wang, Zhongqiu*; Guo, Fangfang; Shi, Donglu; Zhang, Bingbo*; One-pot facile synthesis of PEGylated superparamagnetic iron oxide nanoparticles for MRI contrast enhancement,Materials Science & Engineering C-Materials For Biological Applications, 2014, 41: 161-167, IF: 4.164
23. Jin, Hantao; Liu, Shiyuan*; Guo, Fangfang; Zhang, Bingbo*; Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicity Evaluation for MRI in Mice, Journal of Biomaterials and Tissue Engineering, 2014, 4(6): 443-449, IF: 1.383
22. Wang, Xiaohui; Xing, Xiaohong; Zhang, Bingbo*; Liu, Fengjun; Cheng, Yingsheng*; Shi, Donglu; Surface engineered antifouling optomagnetic SPIONs for bimodal targeted imaging of pancreatic cancer cells, International Journal of Nanomedicine, 2014, 9: 1601-1615, IF: 4.3
21. Yang, Weitao; Guo, Weisheng; Zhang, Bingbo*; Chang, Jin*; Synthesis of Noble Metal Nanoclusters Based on Protein and Peptide as a Template, Acta Chimica Sinica, 2014, 72(12): 1209-1217, IF: 2.131
20. Guo, Weisheng; Chen, Na; Dong, Chunhong; Tu, Yu; Chang, Jin*; Zhang, Bingbo*; One-pot synthesis of hydrophilic ZnCuInS/ZnS quantum dots for in vivo imaging, Rsc Advances, 2013, 3(24): 9470-9475, IF: 3.108
19. Guo, Weisheng; Chen, Na; Tu, Yu; Dong, Chunhong; Zhang, Bingbo*; Hu, Chunhong; Chang, Jin*; Synthesis of Zn-Cu-In-S/ZnS Core/Shell Quantum Dots with Inhibited Blue-Shift Photoluminescence and Applications for Tumor Targeted Bioimaging, Theranostics, 2013, 3(2): 99-108, IF: 8.766
18. Wang, Yan; Ji, Lei; Zhang, Bingbo*; Yin, Peihao; Qiu, Yanyan; Song, Daqian; Zhou, Juying; Li, Qi*; Upconverting rare-earth nanoparticles with a paramagnetic lanthanide complex shell for upconversion fluorescent and magnetic resonance dual-modality imaging, Nanotechnology, 2013, 24(17): 175101, IF: 3.44
17. Zhang, Bingbo*; Jin, Hantao; Li, Yan; Chen, Bingdi; Liu, Shiyuan; Shi, Donglu*; Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity, Journal of Materials Chemistry, 2012, 22(29): 14494-14501, IF: 6.626
16. Kong, Jun; Qiu, Han; Yu, Min; Zhang, Bingbo*; Effect of Structure on the Fluorescent Properties of the Hydrophilic Modified Quantum Dots, Acta Chimica Sinica, 2012, 70(6): 789-795, IF: 2.131
15. Zhang, Bingbo*; Wang, Xiaohui; Liu, Fengjun; Cheng, Yingsheng; Shi, Donglu*; Effective Reduction of Nonspecific Binding by Surface Engineering of Quantum Dots with Bovine Serum Albumin for Cell-Targeted Imaging, Langmuir, 2012, 28(48): 16605-16613, IF: 3.833
14. Liu, Fengjun; Zhang, Bingbo*; Song, Ge; Cheng, Yingsheng*; Gd3+ and RGD Functionalized Quantum Dots for Fluorescent and MR Dual-modality Imaging of Pancreatic Cancer Cells, Chemical Journal of Chinese Universities-Chinese, 2012, 33(2): 378-382, IF: 0.677
13. Zhang, Aili; Tu, Yu; Qin, Songbing; Li, Yan; Zhou, Juying; Chen, Na; Lu, Qiang; Zhang, Bingbo*; Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging, Journal of Colloid and Interface Science, 2012, 372: 239-244, IF: 4.233
12. Li, Yan; Li, Zhe; Wang, Xiaohui; Liu, Fengjun; Cheng, Yingsheng; Zhang, Bingbo*; Shi, Donglu; In Vivo Cancer Targeting and Imaging-Guided Surgery with Near Infrared-Emitting Quantum Dot Bioconjugates, Theranostics, 2012, 2(8): 769-776, IF: 8.766
11. Zhang, Bingbo*; Li, Qi; Yin, Peihao; Rui, Yuanpeng; Qiu, Yanyan; Wang, Yan; Shi, Donglu*; Ultrasound-Triggered BSA/SPION Hybrid Nanoclusters for Liver-Specific Magnetic Resonance Imaging, Acs Applied Materials & Interfaces, 2012, 4(12): 6479-6486, IF: 7.504
10. Zhang, Bingbo; Xing, Da; Lin, Chao; Guo, Fangfang; Zhao, Peng; Wen, Xuejun; Bao, Zhihao*; Shi, Donglu; Improving colloidal properties of quantum dots with combined silica and polymer coatings for in vitro immuofluorenscence assay, Journal of Nanoparticle Research, 2011, 13(6): 2407-2415, IF: 2.02
9. Zhang, Bingbo*; Chen, Bingdi; Wang, Yilong; Guo, Fangfang; Li, Zhuoquan; Shi, Donglu; Preparation of highly fluorescent magnetic nanoparticles for analytes-enrichment and subsequent biodetection, Journal of Colloid and Interface Science, 2011, 353(2): 426-432, IF: 4.233
8. Yang, Qiuhua; Gong, Xiaoqun; Song, Tao; Yang, Jiumin; Zhu, Shengjiang; Li, Yunhong; Cui, Ye; Li, Yingxin; Zhang, Bingbo*; Chang, Jin*; Quantum dot-based immunochromatography test strip for rapid, quantitative and sensitive detection of alpha fetoprotein, Biosensors & Bioelectronics, 2011, 30(1): 145-150, IF: 7.78
7. Zhang, Bingbo; Gong, Xiaoqun; Li, Zhuoquan; Guo, Fangfang; Cai, Shaoyu; Kong, Jilie; Yang, Qiuhua; Ma, Hao; Chang, Jin; Shi, Donglu*; Preparation of Gd-III/Quantum Dots Multimodal Imaging Probes for Disease Diagnosis, Chemical Journal of Chinese Universities-Chinese, 2010, 31(5): 982-985, IF: 0.677
6. Zhang, Bingbo; Gong, Xiaoqun; Lin, Tingting; He, Yanjin; Cheng, Jing; Shan, Shunyang; Chang, Jin*; Preparation and Cell-labeling Function of Monodisperse Core/Shell Structured Quantum Dots/SiO2 with Amino Groups, Chemical Journal of Chinese Universities-Chinese, 2009, 30(2): 246-249, IF: 0.677
5. Zhang, Bingbo; Liang, Xiaofei; Hao, Lijuan; Cheng, Jing; Gong, Xiaoqun; Liu, Xuhui; Ma, Guiping; Chang, Jin*; Quantum dots/particle-based immunofluorescence assay: Synthesis, characterization and application, Journal of Photochemistry and Photobiology B-Biology, 2009, 94(1): 45-50, IF: 2.673
4. Zhang, Bingbo; Gong, Xiaoqun; Hao, Lijuan; Cheng, Jing; Han, Yan; Chang, Jin*; A novel method to enhance quantum yield of silica-coated quantum dots for biodetection, Nanotechnology, 2008, 19(46): 465604, IF: 3.44
3. Zhang, Bingbo; Cheng, Jing; Li, Dena; Liu, Xuhui; Ma, Guiping; Chang, Jin*; A novel method to make hydrophilic quantum dots and its application on biodetection, Materials Science and Engineering B-Advanced Functional Solid-State Materials, 2008, 149(1): 87-92, IF: 2.552
2. Zhang, Bingbo; Cheng, Jing; Gong, Xiaoqun; Dong, Xiaoqing; Liu, Xuhui; Ma, Guiping; Chang, Jin*; Facile fabrication of multi-colors high fluorescent/superparamagnetic nanoparticles, Journal of Colloid and Interface Science, 2008, 322(2): 485-490, IF: 4.233
1. Zhang, Bingbo; Liu, Xuhui; Li, Dena; Tian, Hui; Ma, Guiping*; Chang, Jin*; Preparation of multi-color quantum dots and its application to immunohistochemical analysis, Chinese Science Bulletin, 2008, 53(13): 2077-2083, IF: 1.649

 

Conference Proceedings
1. Nano Imaging: From Probe Design, Synthesis to Translational Medical Applications, 2015 International Molecular Imaging Summit, Xiamen, China, Oct.2015.(Oral Presentation)
2. Protein/Peptide-Mediated Biomineralization of Nanoprobes for Biomedical Theranostics, Academic Seminar on the Establishment of Nano Medicine and Engineering Branch in Chinese Society of Biomedical Engineering (CSBE), Suzhou, China, July, 2015.(Oral Presentation)
3. Gadolinium‐Functionalized Quantum Trigons for Targeted Tumor MR Imaging and Molecular Profiling, The 8th International Conference on Advanced Materials Processing, Gold Coast, QLD, Australia, July, 2014. (Oral Presentation)
4. Nano-based Magnetic Resonance Imaging: From the Probe Preparation, Surface Modification to the Tumor Imaging, The Sixth National Low Field Nuclear Magnetic Resonance (NMR) Technology and its Application Workshop, Hangzhou, China, Oct. 2014.(Oral Presentation)
5. A Novel MRI/Fluorescent Bimodal Nanoprobe for Pancreatic Cancer Detection, The 14th Chinese Biomaterials Congress, Xi’an, China, Sept. 2013.(Oral Presentation)


 

The Institute for Advanced Materials and Nano Biomedicine (iNANO),
Tongji University, 67 Chifeng Road, Shanghai, 200092, China
Tel: +86-021-65988029    Email: inano@tongji.edu.cn
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