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Guotong Xu, Ph.D.

Professor of Life Sciences and Technology
Tongji University 
Email: 
Website:

 
 

EDUCATION

1990-1994    Postdoctoral Fellow, Alcon Laboratory, Inc. R&D Center
1999    Visiting Scholar, National Eye Institute, NIH, USA
1998    Postdoctoral Fellow, Alcon Laboratory, Inc. R&D Center
1995    M.D. in Ophthalmology, PUMC Hospital and CAMS
1994    Ph.D. in Pharmacology, University of North Texas
1985    Master in Ophthalmology, Peking Union Medical College (PUMC) Hospital,
             and CAMS
1982    Bachelor of Medicine, Harbin Medical University


POSITIONS HELD

2008-           Associate Dean and Professor of Tongji Medical School, Shanghai, China
2000-2008      Professor, PI and Deputy Director of Institute of Health Sciences, SIBS,
                          CAS & SJTUSM
1999-Present    Visiting Professor at Fujian Eye Institute
1999-2001      Chief Representative of ORBIS International, Shanghai/New York
1997-1999      Director of Sino-American Rainbow EyeCare Center at Nanjing
1996-1997      VP, Medical Training at Rainbow EyeCare Center, Texas, USA
1994-1996      Assistant Professor of Department of Anatomy and Cell Biology,
                          UNT Health Science Center at Fort Worth, Texas, USA


PROFESSIONAL RECOGNITION

2001-Present    Member of American Academy of Ophthalmology
1988-Present    Member of Association for Research in Vision and Ophthalmology


Biographical Sketch

Dr. Xu has solid training in clinical ophthalmology and ocular pharmacology. His major research activities are in the fields of anti-cataract drug development and using eye diseases as models for aging and systemic metabolic diseases study:
    1. Naphthalene induced cataract model is used to mimic human age-related cataract and a new mechanism is thus proposed to explain the cataract formation. A few drugs tested for cataract therapy have showed positive outcome based on the new mechanism.
    2. The mechanism of diabetic retinopathy in animal model is studied and in this model a new phenomenon is disclosed that neuronal injury occurs as early as the damage to the vascular in retina is made. Based on this finding, several current clinical medicines have been retained and one of them has been confirmed with new function in prevention of DR when delivered in localization at early stage.

SELECTED PUBLICATIONS

Yang YL, Duan Q, Guo TB, Wang XX, Ruan Q, Xu GT, Zhang JW, Lu ZY, Xu M, Lu L, Dai W. BubR1 deficiency results in enhanced activation of MEK and ERKs upon microtubule stresses. Cell Prolif. 2007 Jun;40(3):397-410.

Guo TB, Lu J, Li T, Lu Z, Xu G, Xu M, Lu L, Dai W. Insulin-activated, K+-channel-sensitive Akt pathway is primary mediator of ML-1 cell proliferation. Am J Physiol Cell Physiol. 2005 Aug;289(2):C257-63.

Xu, GX and Xu, GT. Outcome Evaluation on the Surgical Correction of High Myopia with the Phakic IOLs Implantation. American-Chinese Ophthalmology Progress (Chinese Edition). 2002; 1:37-40

Xu, GX and Xu, GT. The Significance of Monitoring System in Assuring Cataract Surgery. Chinese Emergency Diseases. 2001;21:260.

Xu, GX and Xu, GT. Technique Improvement for Highly Difficult Cases in Cataract Surgery with Phacoemulsification and the Handling of the complications. Chinese Journal of Practical Ophthalmology. 2001; 19:12.

Cammarata PR, Xu GT, Huang L, Zhou C, Martin M. Inducible expression of Na+/myo-inositol cotransporter mRNA in anterior epithelium of bovine lens: affiliation with hypertonicity and cell proliferation. Exp Eye Res. 1997 May;64(5):745-57.

Lou MF, Xu GT, Zigler S Jr, York B Jr. Inhibition of naphthalene cataract in rats by aldose reductase inhibitors. Curr Eye Res. 1996 Apr;15(4):423-32.

Lou MF, Xu GT, Cui XL. Further studies on the dynamic changes of glutathione and protein-thiol mixed disulfides in H2O2 induced cataract in rat lenses: distributions and effect of aging. Curr Eye Res. 1995 Oct;14(10):951-8.

Xu GT, Cooke WE. High-angular-momentum transfer during the autoionization of the 6p1/2nd J=3 states of barium. Phys Rev A. 1993 Sep;48(3):2054-2057.

Xu GT, Wang X, Cooke WE. Measurement of the 6p1/2εl branching ratios of the (6pns)J=1 state of barium. Phys Rev A. 1993 Jul;48(1):838-840.

Xu GT, Wang X, Story JG, Cooke WE. Residual-ion orientation after autoionization. Phys Rev A. 1993 Apr; 47(4):R2438-41.

Xu GT, Zigler JS Jr, Lou MF. Establishment of a naphthalene cataract model in vitro. Exp Eye Res. 1992 Jan;54(1):73-81.

Xu GT, Zigler JS Jr, Lou MF. The possible mechanism of naphthalene cataract in rat and its prevention by an aldose reductase inhibitor (ALO1576). Exp Eye Res. 1992 Jan;54(1):63-72.

Russell P, Yamada T, Xu GT, Garland D, Zigler JS Jr. Effects of naphthalene metabolites on cultured cells from eye lens. Free Radic Biol Med. 1991;10(5):255-61.

Xu GT. The blood galactokinase activity in Chinese with reference to congenital cataract. Zhonghua Yan Ke Za Zhi. 1989 Mar;25(2):100-3.

 

The Institute for Advanced Materials and Nano Biomedicine (iNANO),
Tongji University, 67 Chifeng Road, Shanghai, 200092, China
Tel: +86-021-65988029    Email: inano@tongji.edu.cn
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