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Chao Lin, Ph.D.
Peng Zhao, Ph.D. Jinhu Yang, Ph.D.
Fangfang Guo, Ph.D.
Yilong Wang, Ph.D.
Yongyong Li, Ph.D.


Bingbo Zhang, Ph.D.

Research Scientist
The Institute for Advanced Materials & Nano Biomedicine
Tongji University
Address:67 Chifeng Rd. Shanghai, 200092, P.R. China



09/2006- 03/2009 Ph. D,Polymeric materials,Tianjin University

09/2004-07/2006 M.S.,Polymeric materials,Tianjin University

09/2000-07/2004 B.S.,Polymeric materials,Soochow University


 1. Molecular Diagnostics based on Nanomaterials and Nanotechnology
The integration of nanotechnology with biology and medicine is expected to produce major advances in molecular diagnostics. We specialise in design and synthesis of functional nanomaterials, including multi-color quantum dots, rare-earth up-conversion nanoparticles, fluorescent gold nanoclusters, magnetic nanoparticles and metallic nanoparticles. Such nanomaterials can be used as specific bioprobes in the field of molecular diagnostics after labeled with specific ligands (antibody, peptide, DNA, oligonucleotides, aptamer, etc).

2. In vivo Molecular Imaging based on Novel Contrast Agents
The in vivo imaging can be enhanced through the injected contrast agents (CAs). We focus on the design and preparation of novel CAs, including fluorescent probes, MRI CAs, CT CAs, and their multimodal CAs, according to the principles of biocompatibility, fine pharmacokinetics, targeting and clinical feasibility.

Biographical Sketch

Dr. Bingbo Zhang received his Ph. D in polymeric materials from the School of Material Science and Engineering, Tianjin University in 2009. His Ph. D dissertation mainly focused on the nanomaterials and nanotechnology in the filed of biomedical detection. He joined faculty at The Institute for Biomedical Engineering & Nano Science, Tongji University, Shanghai, in 2009. Dr. Zhang has published over 30 refereed papers in international journals with an H-index 13 (June, 2015). His research program is focused on biomedical nanotechnology, biomolecular engineering, molecular imaging, and In vitro molecular diagnostic (IVD). He is a recipient of the “Tongji university talent plan” Award, a member of the Chinese Chemical Society (CCS) and Chinese Society of Micro-Nano Technology (CSMNT). He is also an elected committee member of the Chinese Society of Biomedical Engineering (CSBE) - Branch of Nano medicine and engineering.


Tongji University

21.   Xing, X. H.; Zhang, B. B.*(通讯作者); Wang, X. H.; Liu, F. J.; Shi, D. L.; Cheng, Y. S.*, An "imaging-biopsy" strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots. Biomaterials 2015, 48, 16-25. SCI, IF 8.312
20.   Guo, W. S.; Yang, W. T.; Wang, Y.; Sun, X. L.; Liu, Z. Y.; Zhang, B. B. *(通讯作者); Chang, J.*; Chen, X. Y.*, Color-tunable Gd-Zn-Cu-In-S/ZnS quantum dots for dual modality magnetic resonance and fluorescence imaging. Nano Res 2014, 7 (11), 1581-1591. SCI, IF 6.963
19.   Wang, X. H.; Xing, X. H.; Zhang, B. B. *(通讯作者); Liu, F. J.; Cheng, Y. S.*; Shi, D. L., Surface engineered antifouling optomagnetic SPIONs for bimodal targeted imaging of pancreatic cancer cells. International journal of nanomedicine 2014, 9, 1601-1615. SCI, IF 4.195
18.   Dai, L. L.; Liu, Y. K.; Wang, Z. Q.*; Guo, F. F.; Shi, D. L.; Zhang, B. B. *(通讯作者), One-pot facile synthesis of PEGylated superparamagnetic iron oxide nanoparticles for MRI contrast enhancement. Mat Sci Eng C-Mater 2014, 41, 161-167. SCI, IF 2.736
17.   Jin, H. T.; Liu, S. Y.*; Guo, F. F.; Zhang, B. B. *(通讯作者), Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicity Evaluation for MRI in Mice. J Biomater Tiss Eng 2014, 4 (6), 443-449. SCI, IF 1.167
16.   Yang, W. T.; Guo, W. S.; Zhang, B. B. *(通讯作者); Chang, J.*, Synthesis of Noble Metal Nanoclusters Based on Protein and Peptide as a Template. Acta Chim Sinica 2014, 72 (12), 1209-1217. SCI, IF 0.874
15.   Yang, Q. H.; Wang, X.; Yang, J. M.; Li, X.; Song, T.; Gong, X. Q.; Zhang, B. B. *(通讯作者); Chang, J.*, Development of Quantum Dot-Based Lateral Flow Immunoassay System for Rapid Quantitative Detection of Human Chorionic Gonadotropin. Prog Biochem Biophys 2014, 41 (5), 497-507. SCI, IF 0.29
14.   Guo, W. S.; Chen, N.; Tu, Y.; Dong, C. H.; Zhang, B. B. *(通讯作者); Hu, C. H.; Chang, J.*, Synthesis of Zn-Cu-In-S/ZnS Core/Shell Quantum Dots with Inhibited Blue-Shift Photoluminescence and Applications for Tumor Targeted Bioimaging. Theranostics 2013, 3 (2), 99-108. SCI, IF 7.827
13.   Wang, Y.; Ji, L.; Zhang, B. B. *(通讯作者); Yin, P. H.; Qiu, Y. Y.; Song, D. Q.; Zhou, J. Y.; Li, Q.*, Upconverting rare-earth nanoparticles with a paramagnetic lanthanide complex shell for upconversion fluorescent and magnetic resonance dual-modality imaging. Nanotechnology 2013, 24 (17). SCI, IF 3.672
12.   Guo, W. S.; Chen, N.; Dong, C. H.; Tu, Y.; Chang, J.*; Zhang, B. B. *(通讯作者), One-pot synthesis of hydrophilic ZnCuInS/ZnS quantum dots for in vivo imaging. Rsc Adv 2013, 3 (24), 9470-9475. SCI, IF 3.708
11.   Li, Y.; Li, Z.; Wang, X. H.; Liu, F. J.; Cheng, Y. S.; Zhang, B. B. *(通讯作者); Shi, D. L., In Vivo Cancer Targeting and Imaging-Guided Surgery with Near Infrared-Emitting Quantum Dot Bioconjugates. Theranostics 2012, 2 (8), 769-776. SCI, IF 7.827
10.   Zhang, B. B.*; Jin, H. T.; Li, Y.; Chen, B. D.; Liu, S. Y.; Shi, D. L., Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity. J Mater Chem 2012, 22 (29), 14494-14501. SCI, IF 6.626
9.      Zhang, B. B.*; Li, Q.; Yin, P. H.; Rui, Y. P.; Qiu, Y. Y.; Wang, Y.; Shi, D. L., Ultrasound-Triggered BSA/SPION Hybrid Nanoclusters for Liver-Specific Magnetic Resonance Imaging. Acs Appl Mater Inter 2012, 4 (12), 6479-6486. SCI, IF 5.9
8.      Zhang, B. B.*; Wang, X. H.; Liu, F. J.; Cheng, Y. S.; Shi, D. L., Effective Reduction of Nonspecific Binding by Surface Engineering of Quantum Dots with Bovine Serum Albumin for Cell-Targeted Imaging. Langmuir 2012, 28 (48), 16605-16613. SCI, IF 4.384
7.      Zhang, A. L.; Tu, Y.; Qin, S. B.; Li, Y.; Zhou, J. Y.; Chen, N.; Lu, Q.; Zhang, B. B. *(通讯作者), Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging. J Colloid Interf Sci 2012, 372, 239-244. SCI, IF 3.552
6.      Liu, F. J.; Zhang, B. B. *(通讯作者); Song, G.; Cheng, Y. S.*, Gd3+ and RGD Functionalized Quantum Dots for Fluorescent and MR Dual-modality Imaging of Pancreatic Cancer Cells. Chem J Chinese U 2012, 33 (2), 378-382. SCI, IF 0.954
5.      Kong, J.; Qiu, H.; Yu, M.; Zhang, B. B. *(通讯作者), Effect of Structure on the Fluorescent Properties of the Hydrophilic Modified Quantum Dots. Acta Chim Sinica 2012, 70 (6), 789-795. SCI, IF 0.874
4.      Yang, Q. H.; Gong, X. Q.; Song, T.; Yang, J. M.; Zhu, S. J.; Li, Y. H.; Cui, Y.; Li, Y. X.; Zhang, B. B. *(通讯作者); Chang, J.*, Quantum dot-based immunochromatography test strip for rapid, quantitative and sensitive detection of alpha fetoprotein. Biosens Bioelectron 2011, 30 (1), 145-150. SCI, IF 6.451
3.      Zhang, B. B.*; Chen, B. D.; Wang, Y. L.; Guo, F. F.; Li, Z. Q.; Shi, D. L., Preparation of highly fluorescent magnetic nanoparticles for analytes-enrichment and subsequent biodetection. J Colloid Interf Sci 2011, 353 (2), 426-432. SCI, IF 3.552
2.      Zhang, B. B.; Xing, D.; Lin, C.; Guo, F. F.; Zhao, P.; Wen, X. J.; Bao, Z. H.*; Shi, D. L., Improving colloidal properties of quantum dots with combined silica and polymer coatings for in vitro immuofluorenscence assay. J Nanopart Res 2011, 13 (6), 2407-2415. SCI, IF 2.278
1.      Zhang, B. B.; Gong, X. Q.; Li, Z. Q.; Guo, F. F.; Cai, S. Y.; Kong, J. L.; Yang, Q. H.; Ma, H.; Chang, J.; Shi, D. L.*, Preparation of Gd-III/Quantum Dots Multimodal Imaging Probes for Disease Diagnosis. Chem J Chinese U 2010, 31 (5), 982-985. SCI, IF 0.954

Tianjin University

6.      Zhang, B. B.; Liang, X. F.; Hao, L. J.; Cheng, J.; Gong, X. Q.; Liu, X. H.; Ma, G. P.; Chang, J.*, Quantum dots /particle-based immunofluorescence assay: Synthesis, characterization and application. J Photoch Photobio B 2009, 94 (1), 45-50.  SCI, IF 2.803
5.      Zhang, B. B.; Gong, X. Q.; Lin, T. T.; He, Y. J.; Cheng, J.; Shan, S. Y.; Chang, J., Preparation and Cell-labeling Function of Monodisperse Core/Shell Structured Quantum Dots/SiO2 with Amino Groups. Chem J Chinese U 2009, 30 (2), 246-249. SCI, IF 0.954
4.      Zhang, B. B.; Liu, X. H.; Li, D. N.; Tian, H.; Ma, G. P.; Chang, J.*, Preparation of multi-color quantum dots and its application to immunohistochemical analysis. Chinese Sci Bull 2008, 53 (13), 2077-2083.  SCI, IF 1.365
3.      Zhang, B. B.; Gong, X. Q.; Hao, L. J.; Cheng, J.; Han, Y.; Chang, J.*, A novel method to enhance quantum yield of silica-coated quantum dots for biodetection. Nanotechnology 2008, 19 (46).  SCI, IF 3.672
2.      Zhang, B. B.; Cheng, J.; Li, D. N.; Liu, X. H.; Ma, G. P.; Chang, J.*, A novel method to make hydrophilic quantum dots and its application on biodetection. Mater Sci Eng B-Adv 2008, 149 (1), 87-92.  SCI, IF 2.122
1.      Zhang, B. B.; Cheng, J.; Gong, X. Q.; Dong, X. Q.; Liu, X. H.; Ma, G. P.; Chang, J.*, Facile fabrication of multi-colors high fluorescent/superparamagnetic nanoparticles. J Colloid Interf Sci 2008, 322 (2), 485-490.  SCI, IF 3.552

Conference Proceedings
1. Nano Imaging: From Probe Design, Synthesis to Translational Medical Applications, 2015 International Molecular Imaging Summit, Xiamen, China, Oct.2015.(Oral Presentation)
2. Protein/Peptide-Mediated Biomineralization of Nanoprobes for Biomedical Theranostics, Academic Seminar on the Establishment of Nano Medicine and Engineering Branch in Chinese Society of Biomedical Engineering (CSBE), Suzhou, China, July, 2015.(Oral Presentation)
3. Gadolinium‐Functionalized Quantum Trigons for Targeted Tumor MR Imaging and Molecular Profiling, The 8th International Conference on Advanced Materials Processing, Gold Coast, QLD, Australia, July, 2014. (Oral Presentation)
4. Nano-based Magnetic Resonance Imaging: From the Probe Preparation, Surface Modification to the Tumor Imaging, The Sixth National Low Field Nuclear Magnetic Resonance (NMR) Technology and its Application Workshop, Hangzhou, China, Oct. 2014.(Oral Presentation)
5. A Novel MRI/Fluorescent Bimodal Nanoprobe for Pancreatic Cancer Detection, The 14th Chinese Biomaterials Congress, Xi’an, China, Sept. 2013.(Oral Presentation)


The Institute for Advanced Materials and Nano Biomedicine (iNANO),
Tongji University, 67 Chifeng Road, Shanghai, 200092, China
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