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纳米医学论坛 第六讲
Title: Orthopaedic Implant Bioengineering and Tissue Engineering at UCL IOMS

Reporter:Dr. Chaozong Liu

Inviter: Dr. Yu Cheng
Date&Time: 2015年4月13日(星期一)上午10:00
Location: 同济大学医学院纳米院219会议室(南校区高等技术学院大楼纳米院219室)
Presentation abstract:

UCL is one of the top research universities in Europe and in the top 20 globally, on a research output dominated by its Biomedical and Engineering Faculties. The UCL Institute of Orthopaedics and Musculoskeletal Science (IOMS) is an internationally leading Centre of research and postgraduate training, straddling biomedical and tissue engineering applications. It has an international reputation and a track record for implant innovation and translational research, not least biomimetic materials for engineering & rapid processes for living tissue fabrication. IOMS provides a unique environment for collaboration between scientists, engineers, and clinicians in an Academic Health Sciences Centre model, in order to speed the development of improvements in patient care. IOMS and staff from the Royal National Orthopaedic Hospital lead units of major importance in clinical care and are at the cutting edge of research and development in novel implants and prostheses development; soft and hard tissue engineering; musculoskeletal disorder treatment, bone tumor and osteoporosis; and diseases of childhood.

Tissue engineering involves seeding of cells onto a 3D scaffold, followed by culture within a suitable environment and finally implantation into the body when a mature matrix is formed. The scaffold provides a framework and initial support for the cells to attach, proliferate and differentiate. An ideal scaffold should has the following characteristics: (1) an extensive network of interconnecting pores so that cells can migrate, multiply and attach deep within the scaffolds; (2) channels through which oxygen and nutrients are provided to cells deep inside the scaffold, and the waste products can be easily carried away; (3) biocompatible and has a high affinity for cells to attach and proliferate; and (4) right shape, however complex as desired by the surgeon. Tissue engineering would greatly benefit from such scaffolds. A well defined and controlled architecture that facilitates cellular infiltration and transport of nutrients and waste products is essential. In other words, the scaffold should have the controlled internal architecture such as channels and connected capillary networks to facilitate mass transportation, including provide culture media to the cells deep inside the scaffold and carrying away the metabolic waste, throughout the scaffold/cell construct. The resulting tissue construct should resemble the unique cellular and load bearing characteristics, exhibit similar dynamic properties and replicate as closely as possible the structure, biological properties and function of the native tissue. As with all natural structures, “bones tend to flow into each other”, which makes for a more rigid stronger bone structure. Such structures would also be more sustainable, as they would be made of the most efficient amount of materials.

Our work on musculoskeletal tissue engineering seeks to engineering the architecture of the scaffold, control their compositional and surface properties to allow the scaffold to provide an appropriate physical environment to the cells healthy growth. It is anticipated that this will create new treatments for early osteoarthritis (OA). As a result, the quality of life of OA suffers will be improved allowing a pain free, more active lifestyle.


Dr Chaozong Liu is a non-clinical senior lecturer at UCL Institute of Orthopaedics & Musculoskeletal Science in associate with the Royal National Orthopaedic Hospital Stanmore. He is the MSc in Musculoskeletal Science Course Tutor within UCL Division of Surgery and Interventional Science. He received his Ph D in Orthopaedic Bioengineering from Newcastle University in 2007. Then worked in Oxford University as postdoctoral research fellow, Lecturer in Bioengineering at RGU and Newcastle University for over 5 years prior to the present appointment.

His current research is directed toward biomedical devices processing for enhancing the treatment of musculoskeletal disorders. Specifically, my research interest includes (1) design and development of scaffolds for musculoskeletal tissue engineering and regenerative medicine. (2) Customized medical devices for intervention of musculoskeletal disorders. (3) biomedical device surface processing for regulate protein adsorption and cells attachment.

He has published more than 100 papers include peer-reviewed articles, conference papers, and edited books in the areas of biomaterials and bioengineering. He was elected as a member of EPSRC Peer Review College in 2014, European Research Council Health, Demographic Change and Wellbeing panel member, and was elected as one of the prestigious Visiting Fellows at Oxford St Jhon’s College in 2009. He was one of the founding members of International Society of Bionics Engineering (ISBE) (est 2010), and served on the Editorial board of Journal of Bionics Engineering, and Frontiers in Biomechanics, and on the Open Journal of Biomedical Engineering. He has served as external examiner for Oxford University, Manchester University, Newcastle University and Swansea University.


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