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Blood-Brain Barrier Permeable Gold Nanoparticles: An Efficient Delivery Platform for Enhanced Malignant Glioma Therapy and Imaging

Time: 14:00,

Date: Jul. 2nd, 2014
Location: Room 219, Shi Xun Building , Tongji South Campus ( 67 Chifeng Road )
Reporter: Prof Yu Cheng
Malignant gliomas are primary brain tumors derived from glial origin and account for ~70% of primary brain cancer diagnoses with overall low survival rates. The blood-brain barrier (BBB) remains a formidable obstacle in medicine, preventing efficient penetration of chemotherapeutic and diagnostic agents to malignant gliomas. Searching for ideal platforms that are capable of delivering therapeutic payloads across the BBB is currently under extensive investigation. Currently, nanoparticle-based delivery systems are considered to lead to breakthroughs in malignant glioma treatment. Among the various types of nanomaterials, gold nanoparticles (Au NPs) possess many features such as tunable size, a large surface area-to-volume ratio, flexibility to undergo versatile surface modifications, a high degree of biocompatibility and so on, making them good candidates as carriers for delivering cargoes across the BBB and targeting brain tumors. As a proof of concept, I will first demonstrate that Au NPs without a cargo could cross the BBB efficiently and accumulate in brain tumors after systemic administration. Such a platform could be used to deliver anticancer drugs to cross the BBB, improving overall survival in an orthotopic murine model. Next, I will demonstrate that Au NPs could deliver imaging agents into brain tumors and improve its sensitivity, which could be used for monitoring malignant progression and therapeutic response, in vivo. Furthermore, incorporating targeting reagents into the Au NP platform may further improve its specificity to the cancer cells. This system is a promising delivery platform for crossing the BBB and will find wide applications in malignant glioma therapy and diagnosis.
Prof. Yu Cheng joined the Institute for Biomedical Engineering & Nano Science (iNANO) at the School of Medicine of Tongji University in 2014. She received her B.S. degree in Applied Chemistry and M.S. degree in Organic Chemistry from Wuhan University. In 2011, Prof. Cheng received her Ph.D. degree in Physical Chemistry from Case Western Reserve University. After that Prof. Cheng joined the Brain Tumor Center at The University of Chicago Medical Center as a postdoctoral scholar. Her research focuses on developing translational nanomedicine-related therapies and conducting preclinical tests for cancer treatment. Her research field includes: nanoparticle-based drug delivery system, magnetic nanoparticles for cancer destruction, nanomedicine loaded neural stem cells for targeted cancer treatment, photodynamic therapy, and pharmacokinetics and toxicity of nanomedicine. Prof. Cheng has published a number of articles on the high impact journals in the field of chemistry and medicine including Journal of American Chemistry Society, Advanced Drug Delivery Reviews, Small, and Biomaterials. Her original discoveries and significant results have been highlighted by major media reports such as Yahoo, ScienceDaily, and C&EN.

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