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Engineering Nanoparticles for Tumor Imaging and Therapy

Time: 10:00-11:30AM

Date: Sep. 4th, 2013
Location: Room 219, Shi Xun Building , Tongji South Campus ( 67 Chifeng Road )
Reporter: 谢晋 博士(Assistant Professor,the University of Georgia ,USA)
Our research focuses on the development and evaluation of metal-, polymer- or protein-based nanoparticles applicable in an imaging and/or therapeutic context. The idea is to conceptualize the nanoparticles not as merely tiny aggregates of molecules but rather as platforms with large surface-to-volume ratios. By harnessing the well-developed surface chemistry, one can load a wide range of functionalities onto the particle surface. In this talk, I will focus on two technologies that are being developed in our lab. One is ferritin-based drug delivery carriers. Ferritin is a major iron storage protein found in human and most living organisms. We previously constructed RGD-modified ferritin nanoparticles and confirmed their good tumor selectivity both in vitro and in vivo. Very recently, we found that doxorubicin could be encapsulated into RGD-ferritin nanoparticles at high rate (up to 70 wt%) and delivered to tumors for targeted therapy. The second story is an optical imaging probe made of Cr doped LiGaO3 (LGO:Cr). LGO:Cr can be charged with UV light and then emit in the dark in the near-infrared (NIR) spectrum window for duration of hours. Since LGO does not require concurrent excitation to produce optical signals, the autofluorescence issue that has long been impeding fluorescence imaging is avoided. Indeed, our preliminary data showed a high signal-to-noise ratio, a deep tissue penetration depth, and great sensitivity with LGO-labeled cells or molecules.
Dr. Xie received B.S. in chemistry in 2003 from Nanjing University, China. He came to the U.S. in 2004, at which time he joined a Ph.D. program in the Department of Chemistry at Brown University under the supervision of Professor Shouheng Sun. After obtaining his Ph.D. in chemistry in 2008, Dr. Xie joined Dr. Xiaoyuan Chen’s group in the Molecular Imaging Program at Stanford (MIPS), and in the summer of 2009, he moved with Prof. Chen to the National Institute of Biomedical Imaging and Bioengineering (NIBIB). Dr. Xie joined the faculty of University of Georgia (UGA) in 2011, and has since been an assistant professor at the UGA Department of Chemistry.
Host: 张兵波 博士

The Institute for Advanced Materials and Nano Biomedicine (iNANO),
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