People Home Research Facilities Students Publications News Grants Contact
The 9th SEMINAR of iNANO
Host:Dr. 王祎龙
1 Safety Education
Time:2:00-2:15PM, Dec. 4th (Tue.)
2 如何做好实验记录
Speaker: 王祎龙
Time: 2:15-2:25PM, Dec. 4th(Tue.)
3.Progress Report
Speaker: 马慧 (肺科医院硕士)
Time:2:30-2:55PM, Dec. 4th(Tue.)
Abstract: To establish a detection method for Mycobacterium tuberculosis (MTB) by immunomagnetic beads combined with functionalized fluorescent quantum dots technology, investigate the optimal test condition, and preliminary assess the diagnosis value. MTB standard strain H37Rv was used as detection object, nanobeads and quantum dots were prepared by using wet chemical method, and conjugated separately with MTB binding peptide H8 to obtain immunomagnetic beads and functionalized fluorescent quantum dots, which can react with H37Rv simultaneity and form a ternary complex structure. Based on measuring the fluorescence value and observing under fluorescence microscopy to determine if MTB existed in the sample, a new detection method of MTB using nanotechnology was established. The optimal detection concentration and reaction time of immunomagnetic beads and quantum dots were investigated, and the detection limit and specificity of this detection method were preliminary evaluated by using bacterium suspension and simulation sputum samples.
4.literature Reading
Speaker: 刘敬
Title:Signal amplification using functional nanomaterials for biosensing
Time:3:00-3:30PM, Dec. 4th(Tue.)
Abstract: Signal amplification based on biofunctional nanomaterials has recently attracted considerable attention due to the need for ultrasensitive bioassays and the trend towards miniaturized assays. The biofunctional nanomaterials can not only produce a synergic effect among catalytic activity, conductivity and biocompatibility to accelerate the signal transduction, but also provide amplifie recognition events by high loading of signal tags, leading to a highly sensitive and specific biosensing. Most importantly, nanoscaled materials are in direct contact with the environment, which permits them to act as chemical and biological sensors in single-molecule detection of biomolecules. In this tutorial review, we will focus on recent significant advances in signal amplification strategies combining the cross-disciplines of chemistry, biology, and materials science, and highlight some elegant applications of biofunctional nanomaterials as excellent electronic or optical signal tags in ultrasensitive bioanalysis. The biofunctional nanomaterials- based biosensing opens a series of concepts for basic research and offers new tools for detection of trace amounts of a wide variety of analytes in clinical, environmental, and industrial applications.
Location: Meeting Room 219

The Institute for Advanced Materials and Nano Biomedicine (iNANO),
Tongji University, 67 Chifeng Road, Shanghai, 200092, China
Tel: +86-021-65988029    Email:
Copyright 2009 Tongji University. All rights reserved.

People Home Research Facilities Student News Seminar Yao Qin, Ph.D. Bingbo Zhang, Ph.D.